David McAuley, Pharm.D. Slowing the infusion rate may alleviate symptoms. Minor/Significance Unknown. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator FERAHEME vs Venofer (iron sucrose) - Feraheme The dosage of Venofer is expressed in mg of elemental iron. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Pain, swelling, or redness at the injection site may occur. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . World J Gastroenterol; 16(22): 27202725. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Applies only to oral form of both agents. Anemia. Venofer treatment may be repeated if necessary. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Reactions have occurred following the first dose or subsequent doses of Venofer. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer Venofer early during the dialysis session (generally within the first hour). Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Minor/Significance Unknown. Use Caution/Monitor. This drug is available at a middle level co-pay. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. 1. Applies only to oral form of both agents. *Repeat dose if iron deficiency anemia reoccurs. iron sucrose, captopril. J Lab Clin Med; 111(5):566-70. Avoid or Use Alternate Drug. Use Caution/Monitor. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Drug class: Iron products. Minor (1)iron sucrose, benazepril. Applies only to oral form of both agents. Applies only to oral form of both agents. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Interaction only with oral iron administration. Minor/Significance Unknown. Fulminant symptoms may include general paleness, confusion or episodes of passing out. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. J Lab Clin Med. Minor/Significance Unknown. Manage and view all your plans together even plans in different states. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Anemias. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia Before using, check this product visually for particles or discoloration. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. ONE DOSE. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . The dosage of Venofer is expressed in mg of elemental iron. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Dosing: (a) Divide calculated total cumulate dose . Use Caution/Monitor. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Most Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. This document does not contain all possible drug interactions. Iron Sucrose Monograph for Professionals - Drugs.com Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. (See also Notes section. Venofer may cause clinically significant hypotension. Applies only to oral form of both agents. Calculates iron deficit for dosing iron. 1988 May;111(5):566-70. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. 2010;18(3). Iron Sucrose Protocol - Cmqcc Applies only to oral form of both agents. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Applies only to oral form of both agents. Deferoxamine chelates iron. I. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. It is unlikely . Venofer may reduce the absorption of concomitantly administered oral iron preparations. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Your doctor will do laboratory tests to monitor your response. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Interaction only with oral iron administration. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Applies only to oral form of both agents. Use Caution/Monitor. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Use Caution/Monitor. Do Not Copy, Distribute or otherwise Disseminate without express permission. The dosage of iron sucrose is expressed in mg of elemental iron. Applies only to oral form of both agents. Discard unused portion. Iron Deficiency Calculator Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). If either is present, do not use the liquid. Applies only to oral form of both agents. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Minor/Significance Unknown. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. We comply with the HONcode standard for trustworthy health information. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Minor/Significance Unknown. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Calculosaurus | Ferinject dose calculator Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Venofer has not been studied in patients younger than 2 years old. Feraheme does not contain antimicrobial preservatives. Applies only to oral form of both agents. 2. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Each mL contains 20 mg of elemental iron. Avoid or Use Alternate Drug. Applies only to oral form of both agents. provider for the most current information. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Use Caution/Monitor. 1. Applies only to oral form of both agents. May increase risk of hypotension. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. PDF IRON PRODUCT CHOICE AND DOSE CALCULATION - Blood 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. This drug is available at the lowest co-pay.
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